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Mortality in patients with SEOC is frequently due to the effects
of disseminated abdominal disease on vital organs such as the
gastrointestinal tract and is secondary to distant metastasis.
The latter may be present at the time of diagnosis (stage IV
disease) or can arise following relapse. The GEM models
described here not only recapitulate intraperitoneal spreading
from a primary ovarian tumor but also the most common sites
of distant metastases found in humans: pleura, lung, and liver
(26). Human ovarian tumors harboring mutations in both p53
alleles were more likely associated with high-grade SEOC,
lymph node metastasis, and the development of distant
metastasis (41). In agreement with these data, the progression
to stage III/IV SEOC pathology in the GEM models was
dependent on biallelic mutation/inactivation of p53. While
there was no obvious difference between complete loss or
stabilization of mutant p53, future studies will explore whether
any difference in ethiology or response to therapy results from
t
h
e
s
e
2
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e
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h
a
n
i
s
m
s
.
|
acetaminophen (TYLENOL) 325 mg tablet |
Take 2 tablets by mouth every six hours. Do not take more than 3000 mg in a 24 hour period. |
|
asorbic acid (VITAMIN C) 250 mg tablet |
Take 1 tablet by mouth two times daily with meals. |
|
docusate sodium (COLACE) 100 mg capsule |
Take 1 capsule by mouth two times daily. |
|
enoxaparin (LOVENOX) 80 mg/0.8mL injection syringe |
Inject 0.8 mL into the skin every twelve hours |
|
ferrous sulfate 325 mg (65 mg iron) Tablet |
Take 1 tablet by mouth three times a day with meals |
|
fluconazole (DIFLUCAN) 100 mg tablet |
Take 1 tablet by mouth once daily. Take 2 tablets on the first day, then one tablet daily. |
|
floucinonide (LIDEX) 0.05 % cream |
Apply to affected area two times daily. |
|
furosemide (LASIX) 40 mg tablet |
Take 1 tablet by mouth two times daily. |
|
gapaentin (NEUROTONIN) 300 mg capsule |
Take 2 capsules by mouth three times daily. |
|
ibuprofen (MOTRIN) 600 mg tablet |
Take 1 tablet by mouth every six hours as needed for pain. |
|
iron-vit C-vit B12-folic acid (FE C PLUS) 100-250-25-1 mg-g-mcg-mg Tablet |
Take 1 tablet by mouth once daily. |
|
lidocaine-prilocaine EMLA 2.5-2.5 % cream |
Apply to port site at least 1 hour prior to port access. Cover with plastic wrap. |
|
linezoid (ZYVOX) 600 mg tablet |
Take 600 mg by mouth two times daily. |
|
LORazepam (ATIVAN) 0.5 mg tablet |
Take 1-2 tablets by mouth every four to six hours as needed. |
|
metoprolol succinate (TOPROL XL) 50 mg 24 hr tablet |
Take 50 mg by mouth once daily. |
|
miconazole (LOTRIMIN AF) 2% topical powder |
Apply to the affected area two times daily. |
|
omeprazole (PriLOSEC) 20 mg delayed release capsule |
Take 20 mg by mouth two times daily. |
|
ondansetron (ZOFRAN (AS HYDROCHLORIDE)) 4 mg tablet |
Take 1-2 tablets by mouth two times daily. For 3 days after weekly chemotherapy. |
|
oxyCODONE (OXYCONTIN) 40 mg 12 hr crush resistant tablet |
Take 1 tablet by mouth every twelve hours. |
|
oxyCODONE (OXYCONTIN) 60 mg 12 hr crush resistant tablet |
Take 1 tablet by mouth every twelve hours. |
|
oxyCODONE (ROXICODONE) 5 mg tablet |
Take 1-2 tablets by mouth every four to six hours as needed. |
|
oprochlorperazine (COMPAZINE) 10 mg tablet |
Take 1 tablet by mouth every four to six hours as needed for nausea or vomiting. |
|
senna (SENOKOT) 8.6 mg tablet |
Take 8.6 mg by mouth at bedtime. |
|
simvastatin (ZOCOR) 20 mg tablet |
Take 20 mg by mouth at bedtime. |
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Jana Rosinski is a doctoral student / curator of ephemera who daydreams of living in a working museum (or working in a living museum).
ISSUE FOURTEEN: La Mer Systyle
Jana Rosinski
speaking ovarian cancer
Emma Bolden
Roleplaying in Boardrooms
and Bedrooms
Bathemetry
Shankar Naryan
Psalm from the Old World
Oppenheimer
Heikki Huotari
I'll Be
Autonomic
Vivian Wagner
Notes for a Poem about News
Jesi Bender
The Wedding of Psyche
John Ebersole
The Vine of the Dead
Lana Bella
Plank & Resin
Cocaine Sunset
Travis Macdonald
A The Is The The Is The A
by Lila Zemborain
KJ Hannah Greenberg
Gators Packed Like Multinationals
in Excelsior
Terry Wright
Inside the Roche Limit
Donald Illich
Because an Island is Encouragement